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PARP Antibody (Clone 7A10)

Catalog #: 3023
$325.00

Product Details

Cat # +Size 3023-100
Size 100 µl
Antibody Target PARP
Alternate Name PARP, PPOL, ADPRT, ADPRT1, PARP-1, pADPRT-1, PARP1
Host Mouse
Antibody Type Monoclonal
Isotype Mouse
Accession # P09874
Gene ID 142
Appearance Colorless liquid
Concentration 1 mg/ml
Species Reactivity Human
Application Western blot, Immunocytochemistry
Positive Control Jurkat (1), K562 (2), HeLa (3), Raji (4), THP-1 (5) and SW620 (6) cell lysate.
Application & Usage The antibody performs well on Western blot (1:500-1:2000) and Flow Cytometry studies (1:200-1:400).
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

PARP, a 116 kDa nuclear poly (ADP-ribose) polymerase, appears to be involved in DNA repair in response to environmental stress. This protein can be cleaved by many ICE-like Caspases in vitro and is one of the main cleavage targets of caspase-3 in vivo. In human PARP, the cleavage occurs between Asp214 and Gly215, which separates the PARP amino-terminal DNA binding domain (24 kDa) from the carboxy-terminal catalytic domain (89 kDa). PARP helps cells to maintain their viability; cleavage of PARP facilitates cellular disassembly and serves as a marker of cells undergoing apoptosis.


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