Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]

Anti-PARP Antibody (2B6)

Monoclonal antibody to detect PARP in human samples.
Catalog #: A1109
$285.00

Product Details

Cat # +Size A1109-100
Size 100 µg
Antibody Target PARP
Alternate Name PARP1, ADPRT, PPOL, NAD(+) ADP-ribosyltransferase 1
Host Mouse
Antibody Type Monoclonal
Isotype Mouse IgG1κ
Immunogen A synthetic peptide corresponding to residues before the cleavage site of human PARP-1 was used as immunogen. This antibody recognizes full-length form of PARP and PARP-1 only.
Accession # P09874
Gene ID 142
Appearance Colorless liquid
Concentration 1 mg/ml
Formulation Supplied in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA
Purification Protein G affinity chromatography
Species Reactivity Human
Application WB
Positive Control WB: Jurkat cells
Application & Usage WB: 2-5 µg
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

PARP, a 116 kDa nuclear poly (ADP-ribose) polymerase, appears to be involved in DNA repair in response to environmental stress. This protein can be cleaved by many ICE-like Caspases in vitro and is one of the main cleavage targets of caspase-3 in vivo. In human PARP, the cleavage occurs between Asp214 and Gly215, which separates the PARP amino-terminal DNA binding domain (24 kDa) from the carboxy-terminal catalytic domain (89 kDa). PARP helps cells to maintain their viability; cleavage of PARP facilitates cellular disassembly and serves as a marker of cells undergoing apoptosis.


Why buy BioVision Products?
Innovation
Affordability
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.