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PARP Antibody (Clone 10H)

Catalog #: 3000
$295.00

Product Details

Cat # +Size 3000-100
Size 100 µg
Antibody Target PARP
Alternate Name PARP1, ADPRT, PPOL, NAD(+) ADP-ribosyltransferase 1
Host Mouse
Antibody Type Monoclonal
Isotype Mouse IgG3κ
Accession # NP_001609
Gene ID 142
Appearance Colorless liquid
Concentration 1.0 mg/ml
Formulation 1 mg/ml of IgG purified from mouse ascites by protein A chromatography. Prepared in 20 mM Tris, pH 7.4, 150 mM NaCl, 1% BSA and 0.02% sodium azide.
Purification Chromatography
Species Reactivity All species
Application Western blot, Immunoprecipitation, Immunocytochemistry & ELISA
Positive Control Tested by ICC in rat liver tissues
Application & Usage Immunocytochemistry : 5-20 μg/ml; Western Blot (10 μg/ml using colorimetric methods; <2 μg/ml for ECL); Immunoprecipitation and ELISA
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

PARP, a 116 kDa nuclear poly (ADP-ribose) polymerase, is a highly conserved nuclear enzyme implicated in DNA repair and in the apoptosis response of cells. This protein can be cleaved by many caspases in vitro and is one of the main cleavage targets of caspase-3 in vivo. The cleavage occurs between ASP214 and Gly 215, which separates PARP’s N-terminal DNA binding domain (24 kDa) from its C-terminal catalytic domain (89 kDa). It has been shown that cleavage of PARP facilitates cellular disassembly and inhibition of PARP cleavage attenuates apoptosis in vitro.


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