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Pam3Cys-Ser-(Lys)4, Trihydrochloride

A TLR1/2 agonist
Catalog #: 1700

In stock

$115.00

Product Details

Cat # +Size 1700-100
Size 100 µg
Alternate Name Pam3CSK4 . 3HCl
Appearance Lyophilized solid
CAS # 112208-00-1
Molecular Formula C₈₁H₁₅₆N₁₀O₁₃S. 3HCl
Molecular Weight 1619.62
Purity Confirmed by ESI-MS
Solubility H₂O
SMILES CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O
InChi InChI=1S/C81H156N10O13S/c1-4-7-10-13-16-19-22-25-28-31-34-37-40-55-73(93)86-72(65-105-64-66(104-75(95)57-42-39-36-33-30-27-24-21-18-15-12-9-6-3)63-103-74(94)56-41-38-35-32-29-26-23-20-17-14-11-8-5-2)80(100)91-71(62-92)79(99)89-68(52-44-48-59-83)77(97)87-67(51-43-47-58-82)76(96)88-69(53-45-49-60-84)78(98)90-70(81(101)102)54-46-50-61-85/h66-72,92H,4-65,82-85H2,1-3H3,(H,86,93)(H,87,97)(H,88,96)(H,89,99)(H,90,98)(H,91,100)(H,101,102)/t66?,67-,68-,69-,70-,71-,72-/m0/s1
InChi Key OEDPHAKKZGDBEV-GFPBKZJXSA-N
PubChem CID 130704
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A synthetic triacylated lipopeptide (LP) that mimics the acylated amino terminus of bacterial LPs. Pam3CSK4 is a potent activator of the proinflammatory transcription factor NF-kB. Activation is mediated by the interaction between Toll-like receptor 1 (TLR1) and Toll-like receptor 2 (TLR2).


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