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Anti-PAD4 Monoclonal Antibody (Clone 11F9)

Protein arginine deiminase associated with rheumatoid arthritis
Catalog #: A2314
SKU-Size Size Price Qty
A2314-50 50 µg
$295.00
A2314-100 100 µg
$475.00
More Sizes Get Quote

Product Details

Antibody Target Human PAD4
Alternate Name Peptidyl Arginine Deiminase 4; PDI5; Peptidyl Arginine Deiminase, Type IV; Peptidyl Arginine Deiminase, Type V; Protein-Arginine Deiminase Type IV; Protein-Arginine Deiminase Type-4; EC 3.5.3.15; HL-60 PAD; PADI5; PDI4; PAD; Peptidylarginine Deiminase IV; PADI-H Protein; PADI4
Host Mouse
Antibody Type Monoclonal
Isotype Mouse IgG1
Immunogen Full length recombinant PAD4 protein
Accession # Q9UM07
Gene ID 23569
Appearance Liquid
Formulation In PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide
Purification Protein G purification
Species Reactivity Human
Application Western Blotting, ELISA
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20ºC (6 months), -80ºC (Long term)
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Protein arginine deiminases (PADs) are a family of guanidine-modifying enzymes that catalyze the post-translational modification of target proteins by converting arginine to citrulline. Excessive citrullination of proteins may result in disease states. PAD4 (also known as PADI5) is expressed in neutrophils and in a variety of tissues. PAD4 is known to citrullinate histones, which initiates chromatin decondensation in neutrophils and the subsequent release of neutrophil extracellular traps (NETs), which leads to a lytic form of cell death known as NETosis. The presence of serum PAD4 autoantibodies has been associated with rheumatoid arthritis.


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