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Anti-PAD2 Monoclonal Antibody (Clone 9F7)

Potentially involved in autoimmune diseases
Catalog #: A2312
SKU-Size Size Price Qty
A2312-50 50 µg
$295.00
A2312-100 100 µg
$475.00
More Sizes Get Quote

Product Details

Antibody Target Human PAD2
Alternate Name Peptidyl Arginine Deiminase 2; PDI2; Protein-Arginine Deiminase Type II; EC 3.5.3.15; KIAA0994; PAD-H19; PADI2
Host Mouse
Antibody Type Monoclonal
Isotype Mouse IgG1
Immunogen Full length recombinant human PAD2 protein
Accession # Q9Y2J8
Gene ID 11240
Appearance Liquid
Formulation In PBS, pH 7.2, 50% glycerol, 0.1% BSA, 0.02% sodium azide
Purification Protein G purification
Species Reactivity Human
Application Western Blotting, Immunohistochemistry (IHC)
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Protein arginine deiminases (PADs) are a family of guanidine-modifying enzymes that catalyze the post-translational modification of target proteins by converting arginine to citrulline. Excessive citrullination of proteins may result in disease states. PAD2 is the most widely expressed and evolutionarily conserved family member. Known substrates for PAD2 include myelin basic protein and vimentin, and PAD2 is thought to play a role in the onset and progression of neurodegenerative diseases such as Alzheimer's and multiple sclerosis. PAD2 may also play a role in transcriptional regulation as it is capable of citrullinating histone H3.


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