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Paclitaxel

An Antitumor and antileukemic agent
Catalog #: 1567
$215.00

Product Details

Cat # +Size 1567-25
Size 25 mg
Alternate Name (1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-Diacetoxy-15-{[(2R,3S)-3- (benzoylamino)-2-hydroxy-3- phenylpropanoyl]oxy}-1,9- dihydroxy-10,14,17,17-tetramethyl -11-oxo-6-oxatetracyclo [11.3.1.0~3,10~.0~4,7~] heptadec-13-en-2-yl rel-benzoate
Appearance White solid
CAS # 33069-62-4
Molecular Formula C₄₇H₅₁NO₁₄
Molecular Weight 853.92
Purity ≥99%
Solubility DMSO (50 mg/ml)
SMILES CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C
InChi InChI=1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38-,40-,45+,46-,47+/m0/s1
InChi Key RCINICONZNJXQF-MZXODVADSA-N
PubChem CID 36314
MDL Number MFCD00869953
Handling Protect from moisture
Storage Conditions -20°C
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

An Antitumor and antileukemic agent. Promotes assembly of microtubules and inhibits tubulin disassembly


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Wang, Wei-Jan et al. (2017) Inhibition of the EGFR/STAT3/CEBPD Axis Reverses Cisplatin Cross-resistance with Paclitaxel in the Urothelial Carcinoma of the Urinary Bladder, Clin Cancer Res. 2017 Jan 15;23(2):503-513.
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