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P505-15

A potent, cell-permeable, highly selective, small molecule SYK inhibitor
Catalog #: 9583
SKU-Size Size Price Qty
9583-5 5 mg
$165.00
9583-25 25 mg
$595.00
More Sizes Get Quote

Product Details

Alternate Name 2-[[(1R,2S)-2-aminocyclohexyl]amino]-4-[[3-(2H-1,2,3-triazol-2-yl)phenyl]amino]-5-pyrimidinecarboxamide; PRT062607; PRT2607; BIIB-057
Appearance White solid
CAS # 1370261-96-3; 1370261-97-4
Molecular Formula C₁₉H₂₃N₉O. HCl
Molecular Weight 429.91
Purity ≥98% by HPLC
Solubility DMSO (>25 mg/ml)
SMILES C1CCC(C(C1)N)NC2=NC=C(C(=N2)NC3=CC=CC(=C3)N4N=CC=N4)C(=O)N
InChi InChI=1S/C19H23N9O/c20-15-6-1-2-7-16(15)26-19-22-11-14(17(21)29)18(27-19)25-12-4-3-5-13(10-12)28-23-8-9-24-28/h3-5,8-11,15-16H,1-2,6-7,20H2,(H2,21,29)(H2,22,25,26,27)/t15-,16+/m0/s1
InChi Key TXGKRVFSSHPBAJ-JKSUJKDBSA-N
PubChem CID 44462758
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

P505-15 is a potent, cell-permeable, highly selective, small molecule SYK inhibitor (IC₅₀ = 1 nM) with anti-SYK activity that is at least 80-fold greater than its affinity for other kinases. P505-15 blocks B cell receptor-mediated cell signaling and activation in whole blood (IC₅₀s = 0.27 and 0.28 µM, respectively), as well as Fcɛ receptor 1-mediated basophil degranulation (IC₅₀ = 0.15 µM).


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