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p44/42 MAPK (Erk1/2) Antibody

Catalog #: 3085R
SKU-Size Size Price Qty
3085R-30T 30 µg
$89.00
3085R-100 100 µg
$255.00
More Sizes Get Quote

Product Details

Antibody Target p44/42 MAPK (Erk1/2)
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Synthetic peptide surrounding amino acid 340 of rat ERK2/MAPK1
Accession # P63086.3
Gene ID 116590
Appearance Colorless liquid
Concentration 0.5 mg/ml
Formulation 100 µg (0.5 mg/ml) affinity purified rabbit anti- ERK2/MAPK1polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.01% thimerosal.
Purification Affinity purified
Species Reactivity Human, mouse, rat, sheep, chicken
Application Western blot
Positive Control Mouses 3T3 cell lysate, Jurkat cell lysate, rat kidney tissue lysate
Application & Usage Western Blot analysis (1-4 µg/ml).
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The extracellular signal-regulated kinase 1 and 2 (Erk1 and Erk2) are closely related mitogen activated protein (MAP) kinases that are activated throμgh the extracellular stimulation by many growth factors, mitogens and differentiation promoting agents via a protein kinase cascade. Erk1/2 are activated approximately 1000 fold by phosphorylation of neighboring threonine and tyrosine residues by Mek1 and Mek2. Both sites must be phosphorylated for maximum activity. Erk1/2 kinases are ubiquitously distributed in the nervous system, as well as a broad range of cells and tissues. These two kinases represent proximal kinases in the classical MAP kinase cascade pathway which links growth and differentiation signals at the cell surface (throμgh tyrosine kinase) with transcription in the nucleus.


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Marc Swidergall, EphA2 Is a Neutrophil Receptor for Candida albicans that Stimulates Antifungal Activity during Oropharyngeal Infection. Cell Rep, July 2019;  31291578.
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