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P38delta, Active

Involved in a wide variety of cellular processes
Catalog #: 7754
$295.00

Product Details

Cat # +Size 7754-5
Size 5 μg
Alternate Name p38, mitogen-activated protein kinase 13
Gene Symbol MAPK13
Gene ID 5603
Accession # NM_002754.
Source Baculovirus (Sf9 insect cells)
Appearance Liquid
Physical Form Description Recombinant proteins in storage buffer (50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol).
Molecular Weight 71.0 kDa
Purity by SDS-PAGE ≥80%
Handling Centrifuge the vial prior to opening.
Storage Conditions -80°C
Shipping Conditions Dry Ice
USAGE For Research Use Only! Not to be used in humans

Details

Mitogen-activated protein kinase (MAPK) cascades represent one of the major signal systems used by eukaryotic cells to transduce extracellular signals into cellular responses, and involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The stress-activated protein kinase 4 (SAPK4), or p38 delta, is a member of the MAPK family that are activated by chemical and environmental stresses as well as by proinflammatory cytokines. SAPK4 has a TGY dual phosphorylation motif and is activated in response to cellular stresses and proinflammatory cytokines (1). MAP kinase kinases 3, and 6 can phosphorylate and activate this kinase. Transcription factor ATF2, and microtubule dynamics regulator stathmin have been shown to be the substrates of this kinase (2).


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