Product Details
| abID | ab125643 |
|---|---|
| Cat # +Size | 7754-5 |
| Size | 5 μg |
| Alternate Name | p38, mitogen-activated protein kinase 13 |
| Gene Symbol | MAPK13 |
| Gene ID | 5603 |
| Accession # | NM_002754. |
| Source | Baculovirus (Sf9 insect cells) |
| Appearance | Liquid |
| Physical Form Description | Recombinant proteins in storage buffer (50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol). |
| Molecular Weight | 71.0 kDa |
| Purity by SDS-PAGE | ≥80% |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -80°C |
| Shipping Conditions | Dry Ice |
| USAGE | For Research Use Only! Not to be used in humans |
Details
Mitogen-activated protein kinase (MAPK) cascades represent one of the major signal systems used by eukaryotic cells to transduce extracellular signals into cellular responses, and involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The stress-activated protein kinase 4 (SAPK4), or p38 delta, is a member of the MAPK family that are activated by chemical and environmental stresses as well as by proinflammatory cytokines. SAPK4 has a TGY dual phosphorylation motif and is activated in response to cellular stresses and proinflammatory cytokines (1). MAP kinase kinases 3, and 6 can phosphorylate and activate this kinase. Transcription factor ATF2, and microtubule dynamics regulator stathmin have been shown to be the substrates of this kinase (2).
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