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p-nitro-Pifithrin-α

An inhibitor of p53
Catalog #: B2845
SKU-Size Size Price Qty
B2845-1 1 mg
$65.00
B2845-5 5 mg
$225.00
More Sizes Get Quote

Product Details

Alternate Name 2-(2-imino-4,5,6,7-tetrahydro-1,3-benzothiazol-3-yl)-1-(4-nitrophenyl)ethanone,hydrobromide; 1-(4-Nitrophenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)ethanone, HBr; Pifithrin-alpha, p-Nitro hydrobromide; p-nitro-PFT-α
Appearance A crystalline solid
CAS # 389850-21-9
Molecular Formula C₁₅H₁₆BrN₃O₃S
Molecular Weight 398.3
Purity ≥95%
Solubility ~1mg/ml in DMSO and DMF
SMILES C1CCC2=C(C1)N(C(=N)S2)CC(=O)C3=CC=C(C=C3)[N+](=O)[O-].Br
InChi InChI=1S/C15H15N3O3S.BrH/c16-15-17(12-3-1-2-4-14(12)22-15)9-13(19)10-5-7-11(8-6-10)18(20)21;/h5-8,16H,1-4,9H2;1H
InChi Key NXPCMOGORSWOLH-UHFFFAOYSA-N
PubChem CID 11553038
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

p-nitro-Pifithrin-α is a cell-permeable analog of pifithrin-α. Pifithrin-α is an inhibitor of p53 that blocks p53-dependent apoptosis. p-nitro-Pifithrin-α blocks p53-mediated expression of p21/WAF1 and apoptosis in cortical neurons more potently than pifithrin-α. It suppresses the expression of TGF-β1 in human proximal tubular cells (HK-2 cells) at a concentration of 10 μM. It reduces hepatic triglyceride accumulation and lipotoxicity in mice fed a high fat diet.


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