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P-glycoprotein Antibody

Polyclonal antibody to detect P-glycoprotein in human, mouse, rat samples
Catalog #: 6970
$465.00

Product Details

Cat # +Size 6970-100
Size 100 µg
Antibody Target P-glycoprotein
Alternate Name P-gp, Multidrug resistance protein 1, MDR1, ATP-binding cassette sub-family B (MDR/TAP) member 1, ABCB1
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit Ig
Immunogen Synthetic peptide corresponding to amino acids around position 630 of human P-glycoprotein
Accession # P08183
Gene ID 5243
Appearance Solid
Formulation Each vial contains 5mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3
Purification Immunogen affinity purified antibody
Species Reactivity Human, Mouse, Rat
Application IHC-P, IHC-F
Positive Control IHC: Mouse Kidney, Mouse Intestine, Rat Kidney, Human Lung Cancer tissue
Application & Usage IHC: 1:500-1:1000 of 0.5 mg/ml stock
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

P-gp, also called MDR1 or ABCB1, is a glycoprotein that in humans is encoded by the ABCB1 gene. P-gp is a well-characterized ABC-transporter (which transports a wide variety of xenobiotics across extra- and intracellular membranes). It is an ATP-dependent drug efflux pump with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein functions in the kidneys, liver, blood–brain barrier and the intestinal epithelium.


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