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OSU-03012

A potent PDK1 inhibitor
Catalog #: 2295
SKU-Size Size Price Qty
2295-5 5 mg
$85.00
2295-25 25 mg
$335.00
More Sizes Get Quote

Product Details

Alternate Name 2-amino-N-(4-(5-(phenanthren-2-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)acetamide; OSU03012; AR-12
Peptide Sequence No
Appearance White to off-white solid
CAS # 742112-33-0
Molecular Formula C₂₆H₁₉F₃N₄O
Molecular Weight 460.45
Purity ≥98% by HPLC
Solubility DMSO (>10 mg/ml)
SMILES C1=CC=C2C(=C1)C=CC3=C2C=CC(=C3)C4=CC(=NN4C5=CC=C(C=C5)NC(=O)CN)C(F)(F)F
InChi InChI=1S/C26H19F3N4O/c27-26(28,29)24-14-23(33(32-24)20-10-8-19(9-11-20)31-25(34)15-30)18-7-12-22-17(13-18)6-5-16-3-1-2-4-21(16)22/h1-14H,15,30H2,(H,31,34)
InChi Key YULUCECVQOCQFQ-UHFFFAOYSA-N
PubChem CID 10027278
MDL Number MFCD12912272
Handling Protect from air and light
Storage Conditions -20 ̊C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A novel celecoxib derivative, that acts as a potent inhibitor of 3-phosphoinositide-dependent kinase-1 (PDK1) activity (IC₅₀ = 5 µM for recombinant PDK1). It displays anti-cancer activity in a COX-2-independent manner via inhibition of the phosphatidyl inositol-3-kinase(PI3K)/Akt pathway. OSU03012 is a potent inhibitor of tumor cell growth with an average inhibitory concentration of 1.1 µM across a panel of 60 cancer cell lines.


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