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Osilodrostat

A potent inhibitor of 11β-hydroxylase and aldosterone synthase
Catalog #: B3108
SKU-Size Size Price Qty
B3108-5 5 mg
$150.00
B3108-25 25 mg
$595.00
More Sizes Get Quote

Product Details

Alternate Name LCI699; 4-[(5R)-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl]-3-fluorobenzonitrile
Appearance White powder
CAS # 928134-65-0
Molecular Formula C₁₃H₁₀FN₃
Molecular Weight 227.24
Purity ≥ 98%
Solubility ~45 mg/ml in DMSO
SMILES C1CC2=CN=CN2C1C3=C(C=C(C=C3)C#N)F
InChi InChI=1S/C13H10FN3/c14-12-5-9(6-15)1-3-11(12)13-4-2-10-7-16-8-17(10)13/h1,3,5,7-8,13H,2,4H2/t13-/m1/s1
InChi Key USUZGMWDZDXMDG-CYBMUJFWSA-N
PubChem CID 44139752
MDL Number MFCD25976825
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Osilodrostat is a potent inhibitor of the enzymes 11β-hydroxylase (CYP11B1) and aldosterone synthase (CYP11B2), which catalyze the final steps of cortisol and aldosterone biosynthesis, respectively, in the adrenal cortex. Osilodrostat inhibits 11β-hydroxylase and aldosterone synthase with IC₅₀ values of 2.5 nM and 0.7 nM respectively. It is used to lower cortisol levels in the treatment of Cushing's disease.


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