Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]

OSI-420

A potent EGFR tyrosine kinase inhibitor
Catalog #: B2201

In stock

SKU-Size Size Price Qty
B2201-1 1 mg
$75.00
B2201-5 5 mg
$275.00
More Sizes Get Quote

Product Details

Alternate Name 2-[4-(3-ethynylanilino)-7-(2-methoxyethoxy)quinazolin-6-yl]oxyethanol, hydrochloride; CP-473420
Appearance Crystalline solid
CAS # 183320-51-6
Molecular Formula C₂₁H₂₂ClN₃O₄
Molecular Weight 415.87
Purity ≥98% by HPLC
Solubility DMSO (>5 mg/ml)
SMILES COCCOC1=C(C=C2C(=C1)N=CN=C2NC3=CC=CC(=C3)C#C)OCCO.Cl
InChi InChI=1S/C21H21N3O4.ClH/c1-3-15-5-4-6-16(11-15)24-21-17-12-19(27-8-7-25)20(28-10-9-26-2)13-18(17)22-14-23-21;/h1,4-6,11-14,25H,7-10H2,2H3,(H,22,23,24);1H
InChi Key BUOXOWNQZVIETJ-UHFFFAOYSA-N
PubChem CID 18924996
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

OSI-420 is an active metabolite of Erlotinib (Cat. No. 1588) which is an orally active EGFR tyrosine kinase inhibitor with IC₅₀ of 2 and 20 nM for the inhibition of human EGFR and EGFR autophosphorylation in tumor cells


Why buy BioVision Products?
Innovation
Affordability
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.