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OSI-027

A potent mTOR inhibitor
Catalog #: 2372
SKU-Size Size Price Qty
2372-5 5 mg
$115.00
2372-25 25 mg
$435.00
More Sizes Get Quote

Product Details

Alternate Name 4-(4-amino-5-(7-methoxy-1H-indol-2-yl)imidazo[5,1-f][1,2,4]triazin-7-yl)cyclohexanecarboxylic acid; ASP4786
Appearance Crystalline solid
CAS # 936890-98-1
Molecular Formula C₂₁H₂₂N₆O₃
Molecular Weight 406.44
Purity ≥98% by HPLC
Solubility DMSO (~18 mg/ml)
SMILES COC1=CC=CC2=CC(=C3C4=C(N=CNN4C(=N3)C5CCC(CC5)C(=O)O)N)N=C21
InChi InChI=1S/C21H22N6O3/c1-30-15-4-2-3-13-9-14(25-16(13)15)17-18-19(22)23-10-24-27(18)20(26-17)11-5-7-12(8-6-11)21(28)29/h2-4,9-12H,5-8,22H2,1H3,(H,23,24)(H,28,29)/b17-14-
InChi Key CDNMDRUIGNHEMR-VKAVYKQESA-N
PubChem CID 44224160
MDL Number MFCD20275101
Handling Protect from light and moisture
Storage Conditions -20 ̊C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

OSI-027 is a potent mammalian target of rapamycin (mTOR) kinase inhibitor with potential antineoplastic activity. It binds to and inhibits both the raptor-mTOR (TOR complex 1 or TORC1) and the rictor-mTOR (TOR complex 2 or TORC2) complexes of mTOR, which may result in tumor cell apoptosis and a decrease in tumor cell proliferation.


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