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ORY-1001

A potent and selective LSD1 inhibitor
Catalog #: B1957

In stock

SKU-Size Size Price Qty
B1957-1 1 mg
$95.00
B1957-5 5 mg
$375.00
More Sizes Get Quote

Product Details

Alternate Name N1-((1R,2S)-2-phenylcyclopropyl)cyclohexane-1,4-diamine, dihydrochloride; RG-6016
Appearance Crystalline solid
CAS # 1431326-61-2
Molecular Formula C₁₅H₂₄Cl₂N₂
Molecular Weight 303.27
Purity ≥98% by HPLC
Solubility DMSO (~7 mg/ml)
SMILES C1CC(CCC1N)NC2CC2C3=CC=CC=C3.Cl.Cl
InChi InChI=1S/C15H22N2.2ClH/c16-12-6-8-13(9-7-12)17-15-10-14(15)11-4-2-1-3-5-11;;/h1-5,12-15,17H,6-10,16H2;2*1H/t12?,13?,14-,15+;;/m0../s1
InChi Key UCINOBZMLCREGM-RNNUGBGQSA-N
PubChem CID 71664305
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

ORY-1001 is a potent and selective inhibitor of LSD1 (IC₅₀ < 20 nM). It targets acute myeloid leukemia (AML) stem cells and significantly reduces tumor cell load while increasing survival time in mouse models of AML. ORY-1001 is in clinical trials for cancer treatment.


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