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Oritavancin diphosphate

A semi-synthetic glycopeptide antibiotic
Catalog #: B2713
SKU-Size Size Price Qty
B2713-5 5 mg
B2713-25 25 mg
More Sizes Get Quote

Product Details

Alternate Name (4"R)-22-O-(3-amino-2,3,6-trideoxy-3-C-methyl-α-L-arabino-hexopyranosyl)-N3"-[(4'-chloro[1,1'-biphenyl]-4-yl)methyl]-vancomycin, diphosphate, LY 333328, LY-333328
Peptide Sequence N/A
Appearance White to off-white solid
CAS # 192564-14-0
Molecular Formula C₈₆H₉₇Cl₃N₁₀O₂₆ • 2H₃PO₄
Molecular Weight 1989.09
Purity ≥98% by HPLC
Solubility ~10 mg/ml Water
SMILES OP(O)(O)=O.OP(O)(O)=O.O[[email protected]@H]1[[email protected]@H](O[[email protected]@](O[[email protected]@H](C)[[email protected]@H]2O)([H])C[[email protected]]2(C)NCC3=CC=C(C4=CC=C(Cl)C=C4)C=C3)[[email protected]@H](O[[email protected]](CO)[[email protected]]1O)OC5=C(OC6=CC=C([[email protected]]([[email protected]]7NC([[email protected]](NC)CC(C)C)=O)O)C=C6Cl)C=C([[email protected]](NC([[email protected]@H](NC7=O)CC(N)=O)=O)([H])C(N[[email protected]](C8=O)([H])C9=CC%10=C(O)C=C9)=O)C=C5OC%11=CC=C([[email protected]]([[email protected]](C(N[[email protected]@](C(O)=O)([H])C%12=C%10C(O)=CC(O)=C%12)=O)([H])N8)O[[email protected]]%13([H])O[[email protected]@H](C)[[email protected]](O)[[email protected]@](C)(N)C%13)C=C%11Cl
InChi InChI=1S/C86H97Cl3N10O26.2H3O4P/c1-35(2)22-51(92-7)77(110)98-67-69(105)42-15-20-55(49(88)24-42)120-57-26-44-27-58(73(57)125-84-74(71(107)70(106)59(34-100)122-84)124-62-32-86(6,76(109)37(4)119-62)93-33-38-8-10-39(11-9-38)40-12-17-45(87)18-13-40)121-56-21-16-43(25-50(56)89)72(123-61-31-85(5,91)75(108)36(3)118-61)68-82(115)97-66(83(116)117)48-28-46(101)29-54(103)63(48)47-23-41(14-19-53(47)102)64(79(112)99-68)96-80(113)65(44)95-78(111)52(30-60(90)104)94-81(67)114;2*1-5(2,3)4/h8-21,23-29,35-37,51-52,
PubChem CID 53297457
MDL Number MFCD29472248
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Oritavancin diphosphate is a second-generation, semi-synthetic lipoglycopeptide, that is derived from chloroeremomycin, an analogue of vancomycin. Similar to vancomycin, it contains a core heptapeptide; however, its unique lipophilic side chain provides oritavancin with a prolonged half-life compared to the parent drug. Oritavancin has a multifaceted mechanism of action that displays concentration-dependent effects against gram-positive organisms. Similar to vancomcyin and other glycopeptides, oritavancin inhibits cell wall biosynthesis by binding noncovalently to the D-alanyl-D-alanine terminal ends of the peptidoglycan chain and pentaglycine bridge, thereby inhibiting transglycosylation and transpeptidation.

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