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Orelabrutinib (ICP-022)

A Bruton's tyrosine kinase (BTK) inhibitor
Catalog #: B2789
SKU-Size Size Price Qty
B2789-1 1 mg
$165.00
B2789-5 5 mg
$650.00
More Sizes Get Quote

Product Details

Alternate Name ICP022; 2-(4-phenoxyphenyl)-6-[1-(prop-2-enoyl)piperidin- 4-yl]pyridine-3-carboxamide
Peptide Sequence N/A
Appearance Crystalline solid
CAS # 1655504-04-3
Molecular Formula C₂₆H₂₅N₃O₃
Molecular Weight 427.49
Purity ≥98% by HPLC
Solubility >50 mg/ml DMSO
SMILES C=CC(=O)N1CCC(CC1)C2=NC(=C(C=C2)C(=O)N)C3=CC=C(C=C3)OC4=CC=CC=C4
InChi InChI=1S/C26H25N3O3/c1-2-24(30)29-16-14-18(15-17-29)23-13-12-22(26(27)31)25(28-23)19-8-10-21(11-9-19)32-20-6-4-3-5-7-20/h2-13,18H,1,14-17H2,(H2,27,31)
InChi Key MZPVEMOYADUARK-UHFFFAOYSA-N
PubChem CID 91667513
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Orelabrutinib is a potent and irreversible Bruton's tyrosine kinase (BTK) inhibitor with potential antineoplastic activity. Orelabrutinib prevents both the activation of the B-cell antigen receptor (BCR) signaling pathway and BTK-mediated activation of downstream survival pathways, inhibiting the growth of malignant B-cells that overexpress BTK.


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