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Oprozomib

A next generation proteasome inhibitor
Catalog #: 2386
SKU-Size Size Price Qty
2386-5 5 mg
$115.00
2386-25 25 mg
$460.00
More Sizes Get Quote

Product Details

Alternate Name N-((S)-3-methoxy-1-(((S)-3-methoxy-1-(((S)-1-((R)-2-methyloxiran-2-yl)-1-oxo-3-phenylpropan-2-yl)amino)-1-oxopropan-2-yl)amino)-1-oxopropan-2-yl)-2-methylthiazole-5-carboxamide; ONX-0912; PR-047
Appearance White to off-white solid
CAS # 935888-69-0
Molecular Formula C₂₅H₃₂N₄O₇S
Molecular Weight 532.61
Purity ≥98% by HPLC
Solubility DMSO (~100 mg/ml)
SMILES CC1=NC=C(S1)C(=O)NC(COC)C(=O)NC(COC)C(=O)NC(CC2=CC=CC=C2)C(=O)C3(CO3)C
InChi InChI=1S/C25H32N4O7S/c1-15-26-11-20(37-15)24(33)29-19(13-35-4)23(32)28-18(12-34-3)22(31)27-17(21(30)25(2)14-36-25)10-16-8-6-5-7-9-16/h5-9,11,17-19H,10,12-14H2,1-4H3,(H,27,31)(H,28,32)(H,29,33)/t17-,18-,19-,25+/m0/s1
InChi Key SWZXEVABPLUDIO-WSZYKNRRSA-N
PubChem CID 25067547
Handling Protect from light and moisture
Storage Conditions -20 ̊C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Oprozomib is a next generation, irreversible and selective proteasome inhibitor that displays potent anti-myeloma properties. It potently induces apoptosis in HNSCC cell lines via upregulation of pro-apoptotic Bik.


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