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A selective agonist of GPR132 with anti-cancer activity
Catalog #: B2950
SKU-Size Size Price Qty
B2950-1 1 mg
B2950-5 5 mg
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Product Details

Alternate Name 11-benzyl-7-[[4-(trifluoromethyl)phenyl]methyl]-2,5,7,11-tetrazatricyclo[,6]trideca-1(9),5-dien-8-one
Appearance Solid
CAS # 1807861-48-8
Molecular Formula C₂₄H₂₃F₃N₄O
Molecular Weight 440.46
Purity 99.20%
Solubility 50 mg/ml in DMSO (need ultrasonication)
InChi InChI=1S/C24H23F3N4O/c25-24(26,27)19-8-6-18(7-9-19)15-31-22(32)20-16-29(14-17-4-2-1-3-5-17)12-10-21(20)30-13-11-28-23(30)31/h1-9H,10-16H2
PubChem CID 124085867
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.


ONC212 is a fluorinated imipridone analogue of ONC201. It is an activator of GPCR GPR132 and Gαq signaling, which functions as a tumor suppressor. It induces apoptosis in HPAF-II and AsPC1 cell lines at 20 μM and potently prevents colony formation at 5 μM in HPAF-II cells. It inhibits acute myeloid leukemia growth in vivo and improves overall survival in xenografted mice.

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