Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]



A transcriptional inducer of TRAIL
Catalog #: B3075
SKU-Size Size Price Qty
B3075-5 5 mg
B3075-25 25 mg
More Sizes Get Quote

Product Details

Alternate Name 11-benzyl-7-[(2-methylphenyl)methyl]-2,5,7,11-tetrazatricyclo[,6]trideca-1(9),5-dien-8-one; 7-Benzyl-4-(2-methylbenzyl)-1,2,6,7,8,9-hexahydroimidazo[1,2-A]pyrido[3,4-E]pyrimidin-5(4H)-one; 2,4,6,7,8,9-hexahydro-4-[(2-methylphenyl)methyl]-7-(phenylmethyl)-imidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one; TIC10; TRAIL-inducing compound 10
Appearance White to off-white powder
CAS # 1616632-77-9
Molecular Formula C₂₄H₂₆N₄O
Molecular Weight 386.49
Purity ≥98%
Solubility ~20 mg/ml in DMF, ~10 mg/ml in ethanol, ~1 mg/ml in DMSO
InChi InChI=1S/C24H26N4O/c1-18-7-5-6-10-20(18)16-28-23(29)21-17-26(15-19-8-3-2-4-9-19)13-11-22(21)27-14-12-25-24(27)28/h2-10H,11-17H2,1H3
PubChem CID 73777259
MDL Number MFCD28118993
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.


ONC-201 is an orally active transcriptional inducer of Tumor necrosis factor–related apoptosis-inducing ligand (TRAIL). It induces TRAIL in a p53-independent manner at concentrations of 1.25 μM-5 μM and crosses the blood-brain barrier. It inactivates kinases Akt and extracellular signal–regulated kinase (ERK), leading to the translocation of Foxo3a into the nucleus, where it binds to the TRAIL promoter to up-regulate gene transcription. It causes tumor regression in HCT116 p53−/− xenograft bearing mice.

Why buy BioVision Products?
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.