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OLT1177

A NLRP3 inflammasome inhibitor
Catalog #: B2358

In stock

SKU-Size Size Price Qty
B2358-5 5 mg
$75.00
B2358-25 25 mg
$295.00
More Sizes Get Quote

Product Details

Alternate Name Dapansutrile,3-(methylsulfonyl)-propanenitrile
Appearance White solid
CAS # 54863-37-5
Molecular Formula C₄H₇NO₂S
Molecular Weight 133.17
Purity ≥98%
Solubility >25 mg/ml (DMSO)
SMILES CS(=O)(=O)CCC#N
InChi InChI=1S/C4H7NO2S/c1-8(6,7)4-2-3-5/h2,4H2,1H3
InChi Key LQFRYKBDZNPJSW-UHFFFAOYSA-N
PubChem CID 12714644
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

OLT-1177 is a potent and specific inhibitor of the NLRP3 inflammasome. It significantly decreases IL-1β and IL-18 levels in LPS-stimulated human blood-derived macrophages as well as IL-1β release and caspase-1 activity in human blood neutrophils with no effect on TNF-α levels.


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