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Okadaic acid

based on 1 citations in multiple journalsOkadaic acid14.1 4
A protein phosphatsae inhibitor
Catalog #: 1543
SKU-Size Size Price Qty
1543-025 25 µg
$99.00
1543-100 100 µg
$245.00
More Sizes Get Quote

Product Details

Alternate Name OA
Appearance White solid
CAS # 78111-17-8
Molecular Formula C₄₄H₆₈O₁₃
Molecular Weight 805
Purity >98%
Solubility DMSO (>1 mg/ml) and EtOH (>1 mg/ml)
SMILES CC1CCC2(CCCCO2)OC1C(C)CC(C3C(=C)C(C4C(O3)CCC5(O4)CCC(O5)C=CC(C)C6CC(=CC7(O6)C(CCC(O7)CC(C)(C(=O)O)O)O)C)O)O
InChi InChI=1S/C44H68O13/c1-25-21-34(55-44(23-25)35(46)12-11-31(54-44)24-41(6,50)40(48)49)26(2)9-10-30-14-18-43(53-30)19-15-33-39(57-43)36(47)29(5)38(52-33)32(45)22-28(4)37-27(3)13-17-42(56-37)16-7-8-20-51-42/h9-10,23,26-28,30-39,45-47,50H,5,7-8,11-22,24H2,1-4,6H3,(H,48,49)/b10-9+/t26-,27-,28+,30+,31+,32+,33-,34+,35-,36-,37+,38+,39-,41-,42+,43-,44-/m1/s1
InChi Key QNDVLZJODHBUFM-WFXQOWMNSA-N
PubChem CID 446512
MDL Number MFCD00083455
Handling Protect from moisture. Tumor promoter
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A Potent inhibitor of protein phosphatases 1 and 2A in numerous cell types. Does not affect activity of acid phosphatase, alkaline phosphatase and tyrosine phosphatase. Non-phorbol type tumor promoter. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF-7) and in myeloid cells, but inhibits glucocorticoid-induced apoptosis in T-cell hybridomas.


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Katsha, Ahmed et al. (2017) Activation of EIF4E by Aurora Kinase A Depicts a Novel Druggable Axis in Everolimus-Resistant Cancer Cells, Clin Cancer Res. 2017 Jan 10:1078-0432
Huang et al., Human JC virus small tumour antigen inhibits nucleotide excision repair and sensitises cells to DNA-damaging agents. Mutagenesis, Jul 2015; 30: 475 - 485.
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