Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]

OICR-9429

An inhibitor of the WDR5-MLL interaction
Catalog #: B1256
SKU-Size Size Price Qty
B1256-5 5 mg
$125.00
B1256-25 25 mg
$495.00
More Sizes Get Quote

Product Details

Alternate Name N-[2-(4-Methylpiperazin-1-yl)-5-[3-(morpholin-4- ylmethyl)phenyl]phenyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide
Appearance Yellow solid
CAS # 1801787-56-3 
Molecular Formula C₂₉H₃₂F₃N₅O₃
Molecular Weight 555.59
Purity ≥98% by HPLC
Solubility DMSO (>25 mg/ml)
SMILES CN1CCN(CC1)C2=C(C=C(C=C2)C3=CC(=CC=C3)CN4CCOCC4)NC(=O)C5=CNC(=O)C=C5C(F)(F)F
InChi InChI=1S/C29H32F3N5O3/c1-35-7-9-37(10-8-35)26-6-5-22(21-4-2-3-20(15-21)19-36-11-13-40-14-12-36)16-25(26)34-28(39)23-18-33-27(38)17-24(23)29(30,31)32/h2-6,15-18H,7-14,19H2,1H3,(H,33,38)(H,34,39)
InChi Key DJOVLOYCGXNVPI-UHFFFAOYSA-N
PubChem CID 91623360
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

OICR-9429 is a small-molecule inhibitor of the WDR5-MLL interaction that effectively stops the growth of breast cancer cell lines driven by p53 gene mutation. It also stops the growth of subtype of leukemia cells having specific mutation found in about 9% of the patients with acute myeloid leukemia. WDR5 is a component of a mixed-lineage leukemia (MLL) methyltransferase complex that targets histone 3.


Why buy BioVision Products?
Innovation
Affordability
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.