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OF-1

A selective BRPF1B and BRPF2 bromodomain inhibitor
Catalog #: 9592

In stock

SKU-Size Size Price Qty
9592-5 5 mg
$145.00
9592-25 25 mg
$575.00
More Sizes Get Quote

Product Details

Alternate Name 4-Bromo-N-(2,3-dihydro-6-methoxy-1,3-dimethyl-2-oxo-1H-benzimidazol-5-yl)-2-methylbenzenesulfonamide
Appearance Beige solid
CAS # 919973-83-4
Molecular Formula C₁₇H₁₈BrN₃O₄S
Molecular Weight 440.31
Purity ≥98% by HPLC
Solubility DMSO (>8 mg/ml)
SMILES CC1=C(C=CC(=C1)Br)S(=O)(=O)NC2=C(C=C3C(=C2)N(C(=O)N3C)C)OC
InChi InChI=1S/C17H18BrN3O4S/c1-10-7-11(18)5-6-16(10)26(23,24)19-12-8-13-14(9-15(12)25-4)21(3)17(22)20(13)2/h5-9,19H,1-4H3
InChi Key YUNQZQREIHWDQT-UHFFFAOYSA-N
PubChem CID 35397514
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

OF-1 is a selective BRPF1B and BRPF2 bromodomain inhibitor (Kd values are 100 and 500 nM respectively). OF-1 displays 39-fold selectivity for BRPF1B and BRPF2 over BRD4. It increases thermal stability of full length BRPF1B at 1 µM, in the cellular thermal shift assay. It also demonstrates accelerated fluorescence recovery after photobleaching (FRAP) at 5 µM in the BRPF2 FRAP assay. OF-1 displays modest general cytotoxicity.


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