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Product Details
| Alternate Name | N-(1H-pyrrolo[2,3-c]pyridin-5-yl)benzamide |
|---|---|
| Appearance | Beige solid |
| CAS # | 300586-90-7 |
| Molecular Formula | C₁₄H₁₁N₃O |
| Molecular Weight | 237.26 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO (>30 mg/ml) or EtOH (>20 mg/ml) |
| SMILES | C1=CC=C(C=C1)C(=O)NC2=NC=C3C(=C2)C=CN3 |
| InChi | InChI=1S/C14H11N3O/c18-14(10-4-2-1-3-5-10)17-13-8-11-6-7-15-12(11)9-16-13/h1-9,15H,(H,16,17,18) |
| InChi Key | HWJRIFZDXJKJJN-UHFFFAOYSA-N |
| PubChem CID | 789882 |
| Handling | Protect from air and light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
OAC1 is an Oct4-activating compound that activates expression through the Oct4 gene promoter. In cells expressing Oct4 with Sox2, Klf4, and c-Myc, OAC1 (1 μM) enhances reprogramming efficiency by increasing the rate of production of induced pluripotent stem cells (iPSCs) from embryonic fibroblasts. OAC1 also upregulates mRNA expression of Oct-4, Sox-2 and Nanog, as well as Tet1.
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