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NVP-BSK805 dihydrochloride

A potent and selective ATP-competitive JAK2 inhibitor
Catalog #: B2200
SKU-Size Size Price Qty
B2200-1 1 mg
$75.00
B2200-5 5 mg
$295.00
More Sizes Get Quote

Product Details

Alternate Name 4-(2,6-difluoro-4-(3-(1-(pip4-(2,6-difluoro-4-(3-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)quinoxalin-5-yl)benzyl)morpholine, dihydrochloride
Appearance Crystalline solid
CAS # 1942919-79-0
Molecular Formula C₂₇H₂₈F₂N₆O • 2HCl
Molecular Weight 563.5
Purity ≥98% by HPLC
Solubility DMSO (~ 20 mg/ml)
SMILES C1CNCCC1N2C=C(C=N2)C3=NC4=C(C=CC=C4N=C3)C5=CC(=C(C(=C5)F)CN6CCOCC6)F.Cl.Cl
InChi InChI=1S/C27H28F2N6O.2ClH/c28-23-12-18(13-24(29)22(23)17-34-8-10-36-11-9-34)21-2-1-3-25-27(21)33-26(15-31-25)19-14-32-35(16-19)20-4-6-30-7-5-20;;/h1-3,12-16,20,30H,4-11,17H2;2*1H
InChi Key NUOCAPALWRHKCU-UHFFFAOYSA-N
PubChem CID 57339395
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

NVP-BSK805 is a potent and selective ATP-competitive inhibitor of JAK2 (IC₅₀ = 0.5 nM,). It displays >20-fold selectivity towards JAK1, JAK3 and TYK2.


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