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A potent PI3K inhibitor
Catalog #: 2619
SKU-Size Size Price Qty
2619-5 5 mg
2619-25 25 mg
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Product Details

Alternate Name (5-[2,6-Di(4-morpholinyl)-4-pyrimidinyl]-4-(trifluoromethyl)-2-pyridinamine; BKM-120; Buparlisib
Appearance White solid
CAS # 944396-07-0
Molecular Formula C₁₈H₂₁F₃N₆O₂
Molecular Weight 410.39
Purity >95% by HPLC
Solubility DMSO (~15 mg/ml) or EtOH (~15 mg/ml)
InChi InChI=1S/C18H21F3N6O2/c19-18(20,21)13-9-15(22)23-11-12(13)14-10-16(26-1-5-28-6-2-26)25-17(24-14)27-3-7-29-8-4-27/h9-11H,1-8H2,(H2,22,23)
PubChem CID 16654980
Handling Protect from air and light
Storage Conditions -20 ̊C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


NVP-BKM120 is a potent inhibitor of class I PI3K isoforms; potently blocks both p110α (IC₅₀ = 52 nM) and p110β (IC₅₀ = 166 nM) in vitro. It is much less effective against the class III PI3K Vps34 and mammalian target of rapamycin (mTOR) and has no effect on PI4Kβ and several other kinases. NVP-BKM120 prevents the growth of assorted cancer cell lines when used at 5 μM and inhibits tumor growth in vivo.

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