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A potent, inhibitor of the receptor tyrosine kinase EphB4
Catalog #: 2464
SKU-Size Size Price Qty
2464-5 5 mg
2464-25 25 mg
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Product Details

Alternate Name 4-Methyl-3-[[1-methyl-6-(3-pyridiny l)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino]-N-[3-(t rifluoromethyl)phenyl]benzamide
Appearance Off-white solid
CAS # 940310-85-0
Molecular Formula C₂₆H₂₀F₃N₇O
Molecular Weight 503.48
Purity ≥98% by HPLC
Solubility DMSO (> 100 mg/ml)
SMILES CC1=C(C=C(C=C1)C(=O)NC2=CC=CC(=C2)C(F)(F)F)NC3=NC(=NC4=C3C=NN4C)C5=CN=Canonical SMILES : CC1=C(C=C(C=C1)C(=O)NC2=CC=CC(=C2)C(F)(F)F)NC3=NC(=NC4=C3C=NN4C)C5=CN=CC=C5
InChi InChI=1S/C26H20F3N7O/c1-15-8-9-16(25(37)32-19-7-3-6-18(12-19)26(27,28)29)11-21(15)33-23-20-14-31-36(2)24(20)35-22(34-23)17-5-4-10-30-13-17/h3-14H,1-2H3,(H,32,37)(H,33,34,35)
PubChem CID 16747388
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


A potent, selective small-molecule inhibitor of the receptor tyrosine kinase EphB4 (ED₅₀ = 25 nM). Displays selectivity for EphB4 over >40 other kinases in vitro, including FGFR3. NVP-BHG712 blocks Ephrin receptor autophosphorylation and VEGF-induced angiogenesis.

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