Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]

NVP-BHG712

A potent, inhibitor of the receptor tyrosine kinase EphB4
Catalog #: 2464
SKU-Size Size Price Qty
2464-5 5 mg
$165.00
2464-25 25 mg
$650.00
More Sizes Get Quote

Product Details

Alternate Name 4-Methyl-3-[[1-methyl-6-(3-pyridiny l)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino]-N-[3-(t rifluoromethyl)phenyl]benzamide
Appearance Off-white solid
CAS # 940310-85-0
Molecular Formula C₂₆H₂₀F₃N₇O
Molecular Weight 503.48
Purity ≥98% by HPLC
Solubility DMSO (> 100 mg/ml)
SMILES CC1=C(C=C(C=C1)C(=O)NC2=CC=CC(=C2)C(F)(F)F)NC3=NC(=NC4=C3C=NN4C)C5=CN=Canonical SMILES : CC1=C(C=C(C=C1)C(=O)NC2=CC=CC(=C2)C(F)(F)F)NC3=NC(=NC4=C3C=NN4C)C5=CN=CC=C5
InChi InChI=1S/C26H20F3N7O/c1-15-8-9-16(25(37)32-19-7-3-6-18(12-19)26(27,28)29)11-21(15)33-23-20-14-31-36(2)24(20)35-22(34-23)17-5-4-10-30-13-17/h3-14H,1-2H3,(H,32,37)(H,33,34,35)
InChi Key ZCCPLJOKGAACRT-UHFFFAOYSA-N
PubChem CID 16747388
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A potent, selective small-molecule inhibitor of the receptor tyrosine kinase EphB4 (ED₅₀ = 25 nM). Displays selectivity for EphB4 over >40 other kinases in vitro, including FGFR3. NVP-BHG712 blocks Ephrin receptor autophosphorylation and VEGF-induced angiogenesis.


Why buy BioVision Products?
Innovation
Affordability
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.