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Nutlin-3b

A useful negative control for for non-MDM2 cellular activities
Catalog #: B1227

In stock

SKU-Size Size Price Qty
B1227-1 1 mg
$75.00
B1227-5 5 mg
$295.00
More Sizes Get Quote

Product Details

Alternate Name 4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone
Appearance White to off-white solid
CAS # 675576-97-3
Molecular Formula C₃₀H₃₀Cl₂N₄O₄
Molecular Weight 581.49
Purity ≥98% by HPLC
Solubility DMSO (>14 mg/ml)
SMILES CC(C)OC1=C(C=CC(=C1)OC)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl
InChi InChI=1S/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37)/t27-,28+/m1/s1
InChi Key BDUHCSBCVGXTJM-IZLXSDGUSA-N
PubChem CID 16755649
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Nutlin-3b is less potent (+)-enantiomer of Nutlin-3 as p53 MDM2 inhibitor in comparison with more potent opposite (-)-enantiomer Nutlin-3a. Nutlin-3b may be used as negative control for non-MDM2 cellular activities. Potency of Nutlin-3b is much lower in the wild type p53 cells and has no effect regardless of the status of p53 cells.


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