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Nutlin-3

Mdm2 (mouse double minute 2) antagonist
Catalog #: 1842
SKU-Size Size Price Qty
1842-1 1 mg
$70.00
1842-5 5 mg
$255.00
More Sizes Get Quote

Product Details

Alternate Name (±)-4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one
Appearance White to off-white solid
CAS # 548472-68-0
Molecular Formula C₃₀H₃₀Cl₂N₄O₄
Molecular Weight 581.49
Purity ≥98% by HPLC
Solubility DMSO (~20 mg/ml)
SMILES CC(C)OC1=C(C=CC(=C1)OC)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl
InChi InChI=1S/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37)
InChi Key BDUHCSBCVGXTJM-UHFFFAOYSA-N
PubChem CID 216345
MDL Number MFCD07784509
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cell-permeable. Nutlin-3 is a Mdm2 (mouse double minute 2) antagonist (IC₅₀ = 90 nM for Nutlin-3a and 13.6 µM for Nutlin-3b), p53 pathway activator, and apoptosis inducer.


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