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NU-7441

A potent and selective inhibitor of DNA-dependent protein kinase (DNA-PK) and HDR enhancer
Catalog #: B1117
SKU-Size Size Price Qty
B1117-5 5 mg
$115.00
B1117-25 25 mg
$455.00
More Sizes Get Quote

Product Details

Alternate Name 8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one; KU-57788
Appearance Off-white solid
CAS # 503468-95-9
Molecular Formula C₂₅H₁₉NO₃S
Molecular Weight 413.49
Purity ≥98% by HPLC
Solubility DMSO (~ 2 mg/ml with gentle warming)
SMILES C1COCCN1C2=CC(=O)C3=C(O2)C(=CC=C3)C4=CC=CC5=C4SC6=CC=CC=C56
InChi InChI=1S/C25H19NO3S/c27-21-15-23(26-11-13-28-14-12-26)29-24-17(6-3-9-20(21)24)19-8-4-7-18-16-5-1-2-10-22(16)30-25(18)19/h1-10,15H,11-14H2
InChi Key JAMULYFATHSZJM-UHFFFAOYSA-N
PubChem CID 11327430
MDL Number MFCD11983069
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

NU-7441 is a potent and selective DNA-PK inhibitor (IC₅₀ = 14 nM). Displays selectivity for DNA-PK over a range of kinases including mTOR, PI 3-K, ATM and ATR. Also enhances CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency, and attenuates nonhomologous end-joining (NHEJ).


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