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NSC-19630

A WRN helicase inhibitor
Catalog #: B2665
SKU-Size Size Price Qty
B2665-5 5 mg
$115.00
B2665-25 25 mg
$455.00
More Sizes Get Quote

Product Details

Alternate Name 1-[(1-oxopropoxy)methyl]-1H-pyrrole-2,5-dione; MIRA-1
Appearance White solid
CAS # 72835-26-8
Molecular Formula C₈H₉NO₄
Molecular Weight 183.16
Purity ≥98% by HPLC
Solubility >15 mg/ml Ethanol, >15 mg/ml DMSO
SMILES CCC(=O)OCN1C(=O)C=CC1=O
InChi InChI=1S/C8H9NO4/c1-2-8(12)13-5-9-6(10)3-4-7(9)11/h3-4H,2,5H2,1H3
InChi Key YXEWPGYLMHXLPS-UHFFFAOYSA-N
PubChem CID 227681
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

NSC-19630 (MIRA-1) is a cell-permeable inhibitor of Werner syndrome WRN helicase activity (IC₅₀ = 20 µM) over its ATPase and exonuclease activities, but did not affect other DNA helicases [Bloom syndrome (BLM), Fanconi anemia group J (FANCJ), RECQ1, RecQ, UvrD, or DnaB). Exposure of human cells to NSC 19630 dramatically impairs growth and proliferation, induces apoptosis in a WRN-dependent manner, and results in elevated γ-H2AX and proliferating cell nuclear antigen (PCNA) foci. NSC-19630 exposure leads to delayed S-phase progression, consistent with the accumulation of stalled replication forks, and to DNA damage in a WRN-dependent manner.


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