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A Werner syndrome helicase (WRN) inhibitor
Catalog #: B2664
SKU-Size Size Price Qty
B2664-5 5 mg
B2664-25 25 mg
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Product Details

Alternate Name 1,1'-(2,2-Dimethyl-1,3-propanediyl)bis[3,4-dichloro-1H-pyrrole-2,5-dione
Appearance Off-white solid
CAS # 203115-63-3
Molecular Formula C₁₃H₁₀Cl₄N₂O₄
Molecular Weight 400.04
Solubility ~8 mg/ml DMSO
SMILES CC(C)(CN1C(=O)C(=C(C1=O)Cl)Cl)CN2C(=O)C(=C(C2=O)Cl)Cl
InChi InChI=1S/C13H10Cl4N2O4/c1-13(2,3-18-9(20)5(14)6(15)10(18)21)4-19-11(22)7(16)8(17)12(19)23/h3-4H2,1-2H3
PubChem CID 357621
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


NSC- 617145 is an inhibitor of Werner syndrome helicase (WRN) (IC₅₀ = 250 nM) that inhibits the ATPase, but not exonuclease, activity of WRN helicase in a concentration-dependent manner. It is selective for WRN over BLM, FANCJ, ChlR1, RecQ, and UvrD helicases, only displaying 7% inhibition of RECQ1 at a concentration of 5 µM. It acts synergistically with Mitomycin C (Cat. No. 2713) to induce double-strand breaks and chromosomal abnormalities in vitro.

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