Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]

NSC-687852

A potent ubiquitin C-terminal hydrolase 5 (UCHL5) inhibitor
Catalog #: 2021
SKU-Size Size Price Qty
2021-5 5 mg
$75.00
2021-25 25 mg
$295.00
More Sizes Get Quote

Product Details

Alternate Name 3,5-bis[(4-nitrophenyl)methylidene]-1-prop-2-enoylpiperidin-4-one; (3E,5E)-3,5-bis[(4-nitrophenyl)methylene]-1-prop-2-enoyl-piperidin-4-one; b-AP15
Appearance Pale yellow solid
CAS # 1009817-63-3
Molecular Formula C₂₂H₁₇N₃O₆
Molecular Weight 419.39
Purity ≥98% by HPLC
Solubility DMSO (35 mg/ml)
SMILES C=CC(=O)N1CC(=CC2=CC=C(C=C2)[N+](=O)[O])C(=O)C(=CC3=CC=C(C=C3)[N+](=O)[O-])C1
InChi InChI=1S/C22H17N3O6/c1-2-21(26)23-13-17(11-15-3-7-19(8-4-15)24(28)29)22(27)18(14-23)12-16-5-9-20(10-6-16)25(30)31/h2-12H,1,13-14H2/b17-11+,18-12+
InChi Key GFARQYQBWJLZMW-JYFOCSDGSA-N
PubChem CID 5351435
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cell-permeable. Abrogates the deubiquitinating activity of the 19S regulatory particle by inhibiting ubiquitin C-terminal hydrolase 5 (UCHL5) and ubiquitin-specific peptidase 14 (USP14) resulting in accumulation of polyubiquitin in cells. NSC-687852 induces tumor cell apoptosis and tumor progression in four different solid tumor models in vivo.


Why buy BioVision Products?
Innovation
Affordability
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.