A potent ubiquitin C-terminal hydrolase 5 (UCHL5) inhibitor
Catalog #: 2021 | abID: ab142195

Product Details

abID ab142195
Alternate Name 3,5-bis[(4-nitrophenyl)methylidene]-1-prop-2-enoylpiperidin-4-one; (3E,5E)-3,5-bis[(4-nitrophenyl)methylene]-1-prop-2-enoyl-piperidin-4-one; b-AP15
Appearance Pale yellow solid
CAS # 1009817-63-3
Molecular Formula C₂₂H₁₇N₃O₆
Molecular Weight 419.39
Purity ≥98% by HPLC
Solubility DMSO (35 mg/ml)
SMILES C=CC(=O)N1CC(=CC2=CC=C(C=C2)[N+](=O)[O])C(=O)C(=CC3=CC=C(C=C3)[N+](=O)[O-])C1
InChi InChI=1S/C22H17N3O6/c1-2-21(26)23-13-17(11-15-3-7-19(8-4-15)24(28)29)22(27)18(14-23)12-16-5-9-20(10-6-16)25(30)31/h2-12H,1,13-14H2/b17-11+,18-12+
PubChem CID 5351435
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Cell-permeable. Abrogates the deubiquitinating activity of the 19S regulatory particle by inhibiting ubiquitin C-terminal hydrolase 5 (UCHL5) and ubiquitin-specific peptidase 14 (USP14) resulting in accumulation of polyubiquitin in cells. NSC-687852 induces tumor cell apoptosis and tumor progression in four different solid tumor models in vivo.

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