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NSC 66811

Potent MDM2 inhibitor
Catalog #: 2009
$175.00

Product Details

Cat # +Size 2009-5
Size 5 mg
Alternate Name 2-Methyl-7-[Phenyl(phenylamino)methyl]-8-quinolinol
Appearance White solid
CAS # 6964-62-1
Molecular Formula C₂₃H₂₀N₂O
Molecular Weight 340.42
Purity ≥97% by HPLC
Solubility DMSO (~ 100 mM)
SMILES CC1=NC2=C(C=C1)C=CC(=C2O)C(C3=CC=CC=C3)NC4=CC=CC=C4
InChi InChI=1S/C23H20N2O/c1-16-12-13-18-14-15-20(23(26)22(18)24-16)21(17-8-4-2-5-9-17)25-19-10-6-3-7-11-19/h2-15,21,25-26H,1H3
InChi Key WEENRMPCSWFMTE-UHFFFAOYSA-N
PubChem CID 248986
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cell-permeable. Potent MDM2 (murine double minute 2) inhibitor (Ki = 120 nM) that disrupts MDM2-p53 interaction and activates p53 in cancer cells. Induces p21, p53 and MDM2 accumulation in human colon cancer cells in vitro.


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