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A potent and selective Cdc25A inhibitor
Catalog #: B1809

In stock

SKU-Size Size Price Qty
B1809-1 1 mg
B1809-5 5 mg

Product Details

Alternate Name  6-Chloro-7-[[2-(4-morpholinyl)ethyl]amino]-5,8-quinolinedione
Appearance Red solid
CAS # 383907-43-5
Molecular Formula C₁₅H₁₆ClN₃O₃
Molecular Weight 321.76
Purity ≥98%
Solubility DMSO (~15 mg/ml)
InChi InChI=1S/C15H16ClN3O3/c16-11-13(18-4-5-19-6-8-22-9-7-19)15(21)12-10(14(11)20)2-1-3-17-12/h1-3,18H,4-9H2
PubChem CID 379077
MDL Number MFCD08276924
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


NSC-663284 is a potent, selective and irreversible inhibitor of all Cdc25 isoforms, with preference for Cdc25A (IC₅₀ = 29, 95, and 89 nM for Cdc25A, Cdc25B2, and Cdc25C, respectively). Displays > 20- and > 450-fold selectivity over VHR and PTP1B phosphatases respectively. Arrests cells at both G1 and G2/M phase and blocks cdk2 and cdk1 activation. Blocks proliferation of a range of human tumor cell lines (IC₅₀ = 0.2 - 35 μM).

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