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NSC-23925

A potent plasma membrane glycoprotein 1(Pgp1) inhibitor
Catalog #: 2686
SKU-Size Size Price Qty
2686-5 5 mg
$95.00
2686-25 25 mg
$375.00
More Sizes Get Quote

Product Details

Alternate Name 2-(p-Methoxyphenyl)-α-2-piperidyl-4-quinolinemethanol dihydrochloride, NSC-23925, [2-(4-Methoxyphenyl)4-quinolinyl]-(piperidin-2-y)-methanol dihydrochloride
Appearance White to off-white solid
CAS # 858474-14-3
Molecular Formula C₂₂H₂₄N₂O₂ · 2HCl
Molecular Weight 421.36
Purity ≥98% by HPLC
Solubility H₂O (~5 mg/ml)
SMILES OC(C1NCCCC1)C2=CC(C3=CC=C(OC)C=C3)=NC4=CC=CC=C24.[H]Cl.[H]Cl
InChi InChI=1S/C22H24N2O2.2ClH/c1-26-16-11-9-15(10-12-16)21-14-18(17-6-2-3-7-19(17)24-21)22(25)20-8-4-5-13-23-20;;/h2-3,6-7,9-12,14,20,22-23,25H,4-5,8,13H2,1H3;2*1H
InChi Key WGWOQHWZXLGPNG-UHFFFAOYSA-N
PubChem CID 54601129
MDL Number MFCD22666390
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

NSC-23925 is a potent plasma membrane glycoprotein 1(Pgp1) inhibitor. It inhibits Pgp1 and reverses MDR1 (Pgp1) but does not inhibit MRP or BCRP-mediated MDR. NSC23925 directly inhibits the function of Pgp1 in a dose-dependent manner without altering the total expression level of Pgp1. NSC23925 stimulates ATPase activity of Pgp.


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