Product Details
| abID | ab142144 |
|---|---|
| Cat # +Size | 1907-5 |
| Size | 5 mg |
| Alternate Name | (10-Methyl-9-anthracenyl) methyl carbamimidothioic acid ester hydrochloride; XI-011 |
| Appearance | Yellow solid |
| CAS # | 59474-01-0 |
| Molecular Formula | C₁₇H₁₆N₂S.HCl |
| Molecular Weight | 316.85 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO (100 mM) or EtOH (10 mM) |
| SMILES | CC1=C2C=CC=CC2=C(C3=CC=CC=C13)CSC(=N)N.Cl |
| InChi | InChI=1S/C17H16N2S.ClH/c1-11-12-6-2-4-8-14(12)16(10-20-17(18)19)15-9-5-3-7-13(11)15;/h2-9H,10H2,1H3,(H3,18,19);1H |
| InChi Key | VIBMUYOXJUCEMA-UHFFFAOYSA-N |
| PubChem CID | 16759161 |
| Handling | Protect from moisture |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Cell-permeable. A p53 activator. It strongly activates p53 while selectively inhibiting growth of transformed cells without inducing genotoxicity. It promotes breast cancer cells to undergo apoptosis through activating p53 and inducing expression of proapoptotic genes. Recently, it has been found that activation of p53 by this small molecule is achieved through inhibition of MDMX expression. XI-011 repressed the MDMX promoter, resulting in down-regulation of MDMX mRNA level in MCF-7 cell.
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