NSC 146109 hydrochloride

A p53 activator
Catalog #: 1907 | abID: ab142144

Product Details

abID ab142144
Cat # +Size 1907-5
Size 5 mg
Alternate Name (10-Methyl-9-anthracenyl) methyl carbamimidothioic acid ester hydrochloride; XI-011
Appearance Yellow solid
CAS # 59474-01-0
Molecular Formula C₁₇H₁₆N₂S.HCl
Molecular Weight 316.85
Purity ≥98% by HPLC
Solubility DMSO (100 mM) or EtOH (10 mM)
InChi InChI=1S/C17H16N2S.ClH/c1-11-12-6-2-4-8-14(12)16(10-20-17(18)19)15-9-5-3-7-13(11)15;/h2-9H,10H2,1H3,(H3,18,19);1H
PubChem CID 16759161
Handling Protect from moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Cell-permeable. A p53 activator. It strongly activates p53 while selectively inhibiting growth of transformed cells without inducing genotoxicity. It promotes breast cancer cells to undergo apoptosis through activating p53 and inducing expression of proapoptotic genes. Recently, it has been found that activation of p53 by this small molecule is achieved through inhibition of MDMX expression. XI-011 repressed the MDMX promoter, resulting in down-regulation of MDMX mRNA level in MCF-7 cell.

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