Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]

NSC 146109 hydrochloride

A p53 activator
Catalog #: 1907
$130.00

Product Details

Cat # +Size 1907-5
Size 5 mg
Alternate Name (10-Methyl-9-anthracenyl) methyl carbamimidothioic acid ester hydrochloride; XI-011
Appearance Yellow solid
CAS # 59474-01-0
Molecular Formula C₁₇H₁₆N₂S.HCl
Molecular Weight 316.85
Purity ≥98% by HPLC
Solubility DMSO (100 mM) or EtOH (10 mM)
SMILES CC1=C2C=CC=CC2=C(C3=CC=CC=C13)CSC(=N)N.Cl
InChi InChI=1S/C17H16N2S.ClH/c1-11-12-6-2-4-8-14(12)16(10-20-17(18)19)15-9-5-3-7-13(11)15;/h2-9H,10H2,1H3,(H3,18,19);1H
InChi Key VIBMUYOXJUCEMA-UHFFFAOYSA-N
PubChem CID 16759161
Handling Protect from moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cell-permeable. A p53 activator. It strongly activates p53 while selectively inhibiting growth of transformed cells without inducing genotoxicity. It promotes breast cancer cells to undergo apoptosis through activating p53 and inducing expression of proapoptotic genes. Recently, it has been found that activation of p53 by this small molecule is achieved through inhibition of MDMX expression. XI-011 repressed the MDMX promoter, resulting in down-regulation of MDMX mRNA level in MCF-7 cell.


Why buy BioVision Products?
Innovation
Affordability
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.