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NS-3763

A selective non-competitive kainate receptor antagonist
Catalog #: B1814

In stock

SKU-Size Size Price Qty
B1814-5 5 mg
$125.00
B1814-25 25 mg
$495.00

Product Details

Alternate Name 4,6-Bis(benzoylamino)-1,3-benzenedicarboxylic acid
Appearance Off-white solid
CAS # 70553-45-6
Molecular Formula C₂₂H₁₆N₂O₆
Molecular Weight 404.38
Purity ≥98% by HPLC
Solubility DMSO ( ~10 mg/ml)
SMILES C1=CC=C(C=C1)C(=O)NC2=CC(=C(C=C2C(=O)O)C(=O)O)NC(=O)C3=CC=CC=C3
InChi InChI=1S/C22H16N2O6/c25-19(13-7-3-1-4-8-13)23-17-12-18(16(22(29)30)11-15(17)21(27)28)24-20(26)14-9-5-2-6-10-14/h1-12H,(H,23,25)(H,24,26)(H,27,28)(H,29,30)
InChi Key UUDYZUDTQPLDDP-UHFFFAOYSA-
PubChem CID 4359312
MDL Number MFCD00334657
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

NS-3763 is a selective non-competitive kainate receptor antagonist. It displays selectivity for GLUK5 subunit-containing receptors (IC₅₀ values are 1.6 and > 30 mM for homomeric GLUK5 and GLUK6 receptors respectively). Has minimal activity at AMPA and NMDA receptors (IC₅₀ > 30 μM).


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