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An activator of BKCa (KCa1.1) channels
Catalog #: B2595
SKU-Size Size Price Qty
B2595-5 5 mg
B2595-25 25 mg
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Product Details

Alternate Name N'-[3,5-Bis(trifluoromethyl)phenyl]-N-[4-bromo-2-(2H-tetrazol-5-yl-phenyl]thiourea, NS11021
Peptide Sequence N/A
Appearance White solid
CAS # 956014-19-0
Molecular Formula C₁₆H₉BrF₆N₆S
Molecular Weight 511.24
Purity ≥98% by HPLC
Solubility >50 mg/ml in DMSO
>50 mg/ml in Ethanol
InChi InChI=1S/C16H9BrF6N6S/c17-9-1-2-12(11(6-9)13-26-28-29-27-13)25-14(30)24-10-4-7(15(18,19)20)3-8(5-10)16(21,22)23/h1-6H,(H2,24,25,30)(H,26,27,28,29)
PubChem CID 24825677
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


NS-11021 is a novel KCa1.1 channel activator. At concentrations above 0.3 μM, activates KCa1.1 in a concentration-dependent manner by parallel-shifting the channel activation curves to more negative potentials. Single-channel analysis reveals that NS-11021 increases the open probability of the channel by altering gating kinetics without affecting the single-channel conductance. NS-11021 (10 μM) influenced neither a number of cloned Kv channels nor endogenous Na+ and Ca²⁺ channels (L- and T-type) in guinea pig cardiac myocytes.

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