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NRG4, Human Recombinant

Low affinity ligand for the ERBB4 tyrosine kinase receptor.
Catalog #: P1580

Product Details

Cat # +Size P1580-10
Size 10 μg
Alternate Name Pro-neuregulin-4, membrane-bound isoform, Pro-NRG4, Neuregulin-4, NRG-4
Gene Symbol NRG4
Gene ID 145957
Accession # Q8WWG1
Source E. coli
Appearance Liquid
Physical Form Description In 20 mM Tris-HCl buffer (pH 8.0) containing 30% glycerol, 0.15 M NaCl, 1 mM DTT
Molecular Weight 9.1 kDa (84aa) (N-terminal His-Tag)
Purity by SDS-PAGE >90%
Amino Acid Sequence aa 1-61
Handling Centrifuge the vial prior to opening.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


NRG4 belongs to the neuregulin family and contains 1 EGF-like domain. The protein is low affinity ligand for the ERBB4 tyrosine kinase receptor. It concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligandstimulated tyrosine phosphorylation and activation of the ERBB receptors. NRG4 does not bind to the ERBB1, ERBB2 and ERBB3 receptors. Recombinant human NRG4 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

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