Product Details
| abID | ab287149 |
|---|---|
| Alternate Name | N-(1,4-Dihydro-1,4-dioxo-2-naphthalenyl)-L-tryptophan; (2S)-2-[(1,4-dioxonaphthalen-2-yl)amino]-3-(1H-indol-3-yl)propanoic acid; 1,4-naphthoquinon-2-yl-l-tryptophan |
| Appearance | Orange to Dark Orange-Red powder |
| CAS # | 185351-19-3 |
| Molecular Formula | C₂₁H₁₆N₂O₄ |
| Molecular Weight | 360.36 |
| Purity | 98% |
| Solubility | ~1 mg/ml in Ethanol, ~20 mg/ml in DMSO and DMF |
| SMILES | C1=CC=C2C(=C1)C(=O)C=C(C2=O)NC(CC3=CNC4=CC=CC=C43)C(=O)O |
| InChi | InChI=1S/C21H16N2O4/c24-19-10-17(20(25)15-7-2-1-6-14(15)19)23-18(21(26)27)9-12-11-22-16-8-4-3-5-13(12)16/h1-8,10-11,18,22-23H,9H2,(H,26,27)/t18-/m0/s1 |
| InChi Key | DZZUYZXINNHEGM-SFHVURJKSA-N |
| PubChem CID | 56605052 |
| MDL Number | MFCD21496345 |
| Handling | Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure. |
| Storage Conditions | -20ºC |
| Shipping Conditions | RT |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
NQTrp is an inhibitor of amyloid β (Aβ) oligomerization and fibrillization, with an IC₅₀ of 50 nM for formation of fibrils from Aβ1-42. It reduces the cytotoxic effect of Aβ oligomers in rat PC12 neuronal cell line. It also increases the life span and completely abolishes defective locomotion in a transgenic Alzheimer's disease Drosophila model.
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