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NP-1, Human Recombinant

In addition to antimicrobial activity, NP-1 exhibits chemotactic activity on dendritic cells.
Catalog #: P1333

In stock

SKU-Size Size Price Qty
P1333-5 5 µg
$115.00
P1333-20 20 µg
$295.00
More Sizes Get Quote

Product Details

Alternate Name Neutrophil Peptide-1, alpha Defensin-1, HNP-1, Cryptdin, Vascular endothelial cell growth factor 165 receptor, CD304, NRP, VEGF165R, NRP1, neuronal pentraxin-1, NP1, NPTX1
Gene Symbol NRP1
Gene ID 8829
Accession # O14786
Source E. coli
Appearance Lyophilized
Physical Form Description Lyophilized with no additives.
Molecular Weight 3.4 kDa
Purity by SDS-PAGE ≥ 98.0%
Endotoxin Level <0.1 EU/μg
Biological Activity Determined by its ability to chemoattract immature dendritic cells using a concentration of 1.0-10.0 ng/ml.
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Defensins (α and β) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The α-defensins which include NP-1, NP-2 and NP-3, are distinguished from the β-defensins by the pairing of their three disulfide bonds. In addition to antimicrobial activity, NP-1 exhibits chemotactic activity on dendritic cells. NP-1 is expressed as the C-terminal portion of an inactive precursor protein, which also contains a 19 amino acid N-terminal signal sequence and a 45 amino acid polypeptide. NP-1 contains a six-cysteine motif that forms three intra-molecular disulfide bonds. Recombinant human NP-1 is a 3.4 kDa protein containing 30 amino acid residues.


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