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Notch-2, mouse recombinant

Protein involved in lateral inhibition in embryogenesis and multiple cellular processes through-out adulthood.
Catalog #: 7531
$235.00

Product Details

Cat # +Size 7531-25
Size 25 μg
Alternate Name Neurogenic Locus Notch Homolog Protein 2; Notch B
Gene Symbol NOTCH2
Gene ID 18129
Accession # O35516
Source CHO cells
Appearance Lyophilized
Physical Form Description Lyophilized with PBS
Molecular Weight ~87.0 kDa. The extracellular domain of mouse Notch-2 (aa 26-494) (12 epidermal growth factor-like (EGF) repeats) is fused at the C-terminus to the Fc portion of human IgG1.
Purity by SDS-PAGE ≥95%
Endotoxin Level <0.01 EU/μg purified protein
Reconstitution Instructions Reconstitute with sterile water to 1 mg/ml.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Notch signaling pathway regulates many different cell fate decisions in both vertebrate and invertebrate species. There are 5 canonical Notch ligands in mammals: Jagged-1, Jagged-2, DLL1, DLL3 and DLL4. These can bind to the four Notch receptors Notch 1-4. It is important for pattern formation during development such as neurogenesis, angiogenesis or myogenesis and regulates T cell development and stem cell maintenance. Notch signaling is also involved in cellular processes through-out adulthood. Signaling via Notch occurs between neighbouring cells and both the receptor and its ligands are transmembrane proteins.


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