Product Details
| Cat # +Size | 7531-25 |
|---|---|
| Size | 25 μg |
| Alternate Name | Neurogenic Locus Notch Homolog Protein 2; Notch B |
| Gene Symbol | NOTCH2 |
| Gene ID | 18129 |
| Accession # | O35516 |
| Source | CHO cells |
| Appearance | Lyophilized |
| Physical Form Description | Lyophilized with PBS |
| Molecular Weight | ~87.0 kDa. The extracellular domain of mouse Notch-2 (aa 26-494) (12 epidermal growth factor-like (EGF) repeats) is fused at the C-terminus to the Fc portion of human IgG1. |
| Purity by SDS-PAGE | ≥95% |
| Endotoxin Level | <0.01 EU/μg purified protein |
| Reconstitution Instructions | Reconstitute with sterile water to 1 mg/ml. |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not to be used in humans |
Details
Notch signaling pathway regulates many different cell fate decisions in both vertebrate and invertebrate species. There are 5 canonical Notch ligands in mammals: Jagged-1, Jagged-2, DLL1, DLL3 and DLL4. These can bind to the four Notch receptors Notch 1-4. It is important for pattern formation during development such as neurogenesis, angiogenesis or myogenesis and regulates T cell development and stem cell maintenance. Notch signaling is also involved in cellular processes through-out adulthood. Signaling via Notch occurs between neighbouring cells and both the receptor and its ligands are transmembrane proteins.
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