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nor-NOHA acetate

A potent, selective, and high affinity arginase inhibitor
Catalog #: B2550
SKU-Size Size Price Qty
B2550-5 5 mg
$175.00
B2550-25 25 mg
$695.00
More Sizes Get Quote

Product Details

Alternate Name Nω-hydroxy-nor-Arginine, 2S-amino-4-[[(hydroxyamino)iminomethyl]amino]-butanoic acid, diacetate
Peptide Sequence N/A
Appearance Lyophilized solid
CAS # 1140844-63-8
Molecular Formula C₅H₁₂N₄O₃ • 2C₂H₄O₂
Molecular Weight 296.3
Purity ≥97%
Solubility ~ 5 mg/ml in DMSO
SMILES CC(=O)O.CC(=O)O.C(CN=C(N)NO)C(C(=O)O)N
InChi InChI=1S/C5H12N4O3.2C2H4O2/c6-3(4(10)11)1-2-8-5(7)9-12;2*1-2(3)4/h3,12H,1-2,6H2,(H,10,11)(H3,7,8,9);2*1H3,(H,3,4)/t3-;;/m0../s1
InChi Key PQFYTZJPYBMTCT-QTNFYWBSSA-N
PubChem CID 16760508
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

nor-NOHA acetate is a potent, reversible inhibitor of rat liver arginase with a Ki value of 0.5 µM, which is 20-fold lower than the Ki of 10 µM observed for NOHA. Nor-NOHA is about 40-fold more potent than NOHA as an inhibitor of arginase from mouse macrophages, displaying an IC₅₀ of 10-12 µM.


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