Product Details
| Cat # +Size | 2094-50 |
|---|---|
| Size | 50 μg |
| Alternate Name | Cyclo[3S-amino-9S-methoxy-2S,6E,8S-trimethyl-10-phenyl-4,6- decadienoyl-D-γ-glutamyl-(2Z)-2-(methylamino)-2-butenoyl-(3S)- 3-methyl-D-β-aspartyl-L-arginyl] |
| Appearance | Liquid |
| Formulation | In Ethanol |
| CAS # | 118399-22-7 |
| Molecular Formula | C₄₁H₆₀N₈O₁₀ |
| Molecular Weight | 824.96 |
| Purity | ≥95% |
| SMILES | CC=C1C(=O)NC(C(C(=O)NC(C(=O)NC(C(C(=O)NC(CCC(=O)N1C)C(=O)O)C)C=CC(=CC(C)C(CC2=CC=CC=C2)OC)C)CCCN=C(N)N)C)C(=O)O |
| InChi | InChI=1S/C41H60N8O10/c1-8-31-38(54)48-34(40(57)58)26(5)36(52)46-29(15-12-20-44-41(42)43)37(53)45-28(25(4)35(51)47-30(39(55)56)18-19-33(50)49(31)6)17-16-23(2)21-24(3)32(59-7)22-27-13-10-9-11-14-27/h8-11,13-14,16-17,21,24-26,28-30,32,34H,12,15,18-20,22H2,1-7H3,(H,45,53)(H,46,52)(H,47,51)(H,48,54)(H,55,56)(H,57,58)(H4,42,43,44)/b17-16+,23-21+,31-8+ |
| InChi Key | IXBQSRWSVIBXNC-ANPQUZCZSA-N |
| PubChem CID | 6437077 |
| MDL Number | MFCD16659855 |
| Handling | Protect from air and moisture |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Nodularin is a hepatotoxic monocylic pentapeptide produced by cyanobacterium Nodularia spumigena. It is a potent inhibitor of protein phosphatase types 1 (PP1) and 2A (PP2A), exhibiting IC₅₀ values of 1.8 and 0.026 nM, respectively. It inhibits PP2B only at higher concentrations ( IC₅₀ = 1.8 µM).
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