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NNT-1/BCSF-3, Human Recombinant

Promotes the survival of chick embryonic motor and sympathetic neurons
Catalog #: P1332
SKU-Size Size Price Qty
P1332-2 2 µg
P1332-10 10 µg
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Product Details

Alternate Name Novel Neurtrophin-1, NNT-1, B-Cell-Stimulating Factor-3, BSF-3, Cardiotrophin-like cytokine, Cardiotrophin-like cytokine factor 1 (CLCF1), CLCF1, BSF3, CLC, NNT1
Gene Symbol CLCF1
Gene ID 23529
Accession # Q9UBD9
Source E. coli
Appearance Lyophilized
Physical Form Description Lyophilized with no additives.
Molecular Weight 22.4 kDa
Purity by SDS-PAGE ≥ 98.0%
Endotoxin Level <0.1 EU/ μg endotoxin, tested
Biological Activity NT-1/BCSF-3 weakly supports chick E8 DRG neurite outgrowth at a concentration of 1.0 ng/ml.
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans


NNT-1/BCSF-3 is a neurotrophic factor with B-cell stimulating capabilities. Expressed in lymph nodes and spleen, NNT-1/BCSF-3 binds and activates glycoprotein 130 (gp130) and leukemia inhibitory factor receptor member β (LIFR-β) and induces tyrosine phosphorylation of these receptors. In vitro, it supports the survival of chick embryo motor and sympathetic neurons. In mice, NNT-1/BCSF-3 induces serum amyloid A, causes body weight loss and B cell hyperplasia associated with increased in serum IgG and IgM. Human Recombinant NNT-1/BCSF-3 is a 22.4 kDa protein containing 199 amino acid residues.

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