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NNMT Antibody

Polyclonal Antibody to detect NNMT in human samples
Catalog #: 6673
SKU-Size Size Price Qty
6673-30T 30 μg
$89.00
6673-100 100 μg
$265.00
More Sizes Get Quote

Product Details

Antibody Target NNMT
Alternate Name Nicotinamide N-methyltransferase
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Recombinant protein of human Nicotinamide N-Methyltransferase
Accession # P40261
Gene ID 4837
Appearance Colorless liquid
Concentration 0.5 mg/ml
Formulation 100 µg (0.5 mg/ml) of antibody in PBS pH 7.2 containing 0.01 % BSA, 0.01 % thimerosal, and 50 % glycerol.
Purification Affinity Purified Antibody
Species Reactivity Human
Application Western blot
Positive Control Western Blot: Recombinant protein
Application & Usage Western blot: 1-4 µg/ml.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. NNMT is an important cytosolic methyltransferase catalyzing the N-methylation of nicotinamide, pyridines and structural analogs, playing a crucial role in the biotransformation and detoxification of many xenobiotic compounds. In the N-methylation process, NNMT uses S-adenosyl methionine as the methyl donor and nicotinamide as methyl acceptor. NNMT is mostly expressed in the liver, and a lower expression is seen in the kidney, lung, skeletal muscle, placenta and heart. It may also play an important role in regulating biological processes related to N-methyl nicotinamide such as anti-inflammatory, anti-thrombotic, vasoprotective, and gastroprotective properties. Increased NNMT activity was reported in many kinds of tumors. NNMT is a potential biomarker and therapeutic target in cancer diagnosis and treatment. NNMT serum levels have significance in the premature detection and in the management of patients with colorectal cancer.


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